We only have two sets of teeth to last us a lifetime. But cichlid fish in Lake Malawi have an endless supply. Whenever they lose a tooth...
We only have two sets of teeth to last us a lifetime.
But cichlid fish in Lake Malawi have an endless supply. Whenever they lose a tooth, a new one drops neatly into place.
Now
new research suggests humans could one day be able to regrow their own
teeth in the same way as cichlids, spelling the end for dentures.
Working with
hundreds of cichlids, scientists are attempting to find out which genes
help the fish maintain their teeth throughout their adult lives.
By
studying the chemicals that change cells into teeth and taste buds in
embryonic fish, they hope to be able to turn on the tooth regrowing
mechanism in humans.
The
research, which also included looking at dental differences in mice,
showed the process could remain active for longer than previously
thought.
This suggests the process could be triggered in human adults.
Professor
Todd Streelman, of Georgia Institute of Technology, said: 'We've
uncovered developmental plasticity between teeth and taste buds.
'We are trying to understand the pathways that mediate the fate of cells toward either dental or sensory development.
Working with hundreds of cichlids,
scientists are beginning to understand how they maintain their hundreds
of teeth throughout their adult lives. The research suggests humans
could one day be able to regrow their own teeth in the same way as
cichlids, spelling the end for dentures
'The
potential applications to humans makes this interesting to everybody
who has dealt with dental issues at one time or another in their lives.'
SCIENTISTS SAY URINE COULD HELP REGROW LOST TEETH
Chinese scientists predict stem cells obtained from urine could allow humans to regrow lost teeth.
In 2013, the Chinese Academy of Sciences created tooth-like structures in mice using these stem-cells.
They claim one day bioengineered 'tooth buds' could be transplanted into humans who have lost their teeth.
The
primitive tooth-like structures are the first solid tissues to be
developed using a technique in which discarded cells from human waste
can be coaxed into becoming stem cells.
The scientists used a new system of tissue culture to grow cells into tiny structures resembling teeth.
The
stem cells were generated from urine, based on previous studies which
have shown discarded cells in human waste can be coaxed into becoming
pluripotent stem cells (iPSCs).
These can then themselves generate many different cell types, including neurons and heart muscle cells.
According to Cell Regeneration Journal, the tooth buds are the first solid organs or tissues made from iPSCs.
Lake Malawi's extraordinary population of cichlids evolved from a single ancestor thousands of years ago.
It's
hoped the fish could hold the key to helping almost 60 percent of the
human population who have lost all their teeth by the time they reach
sixty.
Beyond the painful dental health issues, this can causes medical and nutritional problems that can shorten life.
The
study, published in the journal Proceedings of the National Academy of
Sciences, found the teeth and taste buds grow from the same surface
tissues in embryonic fish.
Unlike humans fish have no tongues so their taste buds are mixed in with their teeth - sometimes in adjacent rows.
The Lake Malawi cichlids have adapted their teeth and taste buds to thrive in the unique conditions where they live.
One species eats plankton and needs few teeth because it locates its food by sight and swallows it whole.
Another
lives on algae which has to be scraped or snipped from rocky lake
formations - needing both many more teeth and more taste buds to
distinguish food.
By
studying the genetic differences in the fish - and mice - the
scientists believe it's possible the same tissue in humans could also be
able to regenerate new teeth.
By
bathing embryonic fish in chemicals that influence the developmental
pathways, they boosted the growth of taste buds at the expense of teeth.
Pictured is a microscopic image of a
Cichlid mouth with teeth (in orange). By studying the genetic
differences in the fish - and mice - the scientists believe it's
possible the same tissue in humans could also be able to regenerate new
teeth
These
changes began just five or six days after the fish eggs were fertilised
at a stage when the fish had eyes and a brain - but were still
developing jaws.
Professor
Streelman said: 'There appear to be developmental switches that will
shift the fate of the common epithelial cells to either dental or
sensory structures.'
Teeth
and taste buds begin in the same kind of epithelial tissue in the
developing jaws of embryonic fish and differentiate later forming teeth
with hard enamel - or soft taste buds.
'It's not until later in the development of a tooth that it forms enamel and dentine,' Streelman added.
'At the earliest stages of development, these structures are really very similar.
'It was not previously thought development would be so plastic for structures that are so different in adult fish.
'Ultimately this suggests the epithelium in a human's mouth might be more plastic than we had previously thought.
'The
direction our research is taking, at least in terms of human health
implications, is to figure out how to coax the epithelium to form one
type of structure or the other.'
But the researchers would also need to understand how nerves and blood vessels grow into teeth to make them viable.
They
are now working to find out how far into adulthood the plasticity
between teeth and taste buds extends - and what can trigger the change.
COMMENTS